Because of this, it's critical to evaluate both your hand and the possible effects of your discards on the hands of your opponents. For instance, it might be a sign that an opponent is almost done with a meld involving thyono 567 slotsose cards if you observe that they have been regularly drawing cards from the discard pile. In these situations, it might make more sense to keep any relevant cards rather than throwing them away. On the other hand, there are situations in which keeping some cards can make it more difficult to advance. It might be time to let go of high-point cards if you continuously hold onto them even though they don't contribute to any possible melds.
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