If you have two aces & a joker, for example, you can use the joker as a third ace or as part of a run with other consecutive cards like that. Jokers are useful tools, but they should only be employed sparingly. Missed chanceslots animals to form more conventional melds with actual cards in hand can result from an over-reliance on jokers. Also, it's critical to modify your strategy if you see that an opponent has taken a joker from the discard pile; they might be getting close to finishing their melds sooner than you had expected. Monitoring the number of jokers still in play & who is in possession of them can give you important information about what your opponents might do.
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